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About Hua

China-Western Joint Innovation

Hua Medicine is a clinical-stage innovative drug development company in China focused on developing novel therapies for patients worldwide with unmet medical needs. We have advanced a first-in-class oral drug dorzagliatin for the treatment of type 2 diabetes into NDA-enabling stage. In anticipation of successful Phase 3 registration trials, we have commenced rolling NDA submission and preparation for initial product launch in China.

2011
Established
70%
R&D Team
100+
Clinical Center
2011
Established
70%
R&D Team
100+
Clinical Center
Scientific R&D

Research Area

Glucokinase Activator(GKA) --- Dorzagliatin(HMS5552)is a b first-in-class oral drug for the treatment of type 2 diabetes that under developed by Hua Medicine. Dorzagliatin has brand new mechanism and structure.
mGluR5 negative allosteric modulators (NAM) as potential novel treatment for levodopa-induced dyskinesia in Parkinson’s disease (PD-LID) and plan to initiate clinical studies in the near future.
Glucokinase Activator(GKA) --- Dorzagliatin(HMS5552)is a b first-in-class oral drug for the treatment of type 2 diabetes that under developed by Hua Medicine. Dorzagliatin has brand new mechanism and structure.
mGluR5 negative allosteric modulators (NAM) as potential novel treatment for levodopa-induced dyskinesia in Parkinson’s disease (PD-LID) and plan to initiate clinical studies in the near future.
Type 2 Diabetes Therapy

The Concept of Glucose Homeostasis

&
In Healthy Humans

Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.

&
In Patients with Type 2 Diabetes

Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.

&
Glucokinase Activator (GKA) Restores

A GKA can repair defective GK function and restore glucose homeostasis, thus alleviate diabetes by addressing one of the root causes.

&
In Healthy Humans

Glucose concentrations for healthy individuals are maintained within a narrow range of 4-6.5mM --- glucose homeostasis, and regulated by various pathways. As the glucose sensor, glucokinase (GK) senses changes in glucose levels, which is essential for maintaining whole-body glucose homeostasis.

&
In Patients with Type 2 Diabetes

Impaired GK activity and function in T2D patients results in defects in glucose sensing, leading to disrupted glucose homeostasis.

&
Glucokinase Activator (GKA) Restores

A GKA can repair defective GK function and restore glucose homeostasis, thus alleviate diabetes by addressing one of the root causes.

GK
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